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Ausgewählte Veröffentlichungen

... der Arbeitsgruppe Onkologie unter Leitung von Herrn Dr. Hübbers

  1. M. F. Meyer, J. Meinrath, J. Seehawer, A. Lechner, M. Odenthal, A. Quaas, R. Semrau, C. U. Huebbers, S. Marnitz, R. Büttner, and D. Beutner, “The relevance of the lymph node ratio as predictor of prognosis is higher in HPV-negative than in HPV-positive oropharyngeal squamous cell carcinoma.,” Clin Otolaryngol, vol. 59, p. 225, Jul. 2017.
  2. A. Lechner, H. Schlößer, S. I. Rothschild, M. Thelen, S. Reuter, P. Zentis, A. Shimabukuro-Vornhagen, S. Theurich, K. Wennhold, M. Garcia-Marquez, L. Tharun, A. Quaas, A. Schauss, J. Isensee, T. Hucho, C. Huebbers, M. V. Bergwelt-Baildon, and D. Beutner, “Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.,” Oncotarget, vol. 8, no. 27, pp. 44418–44433, Jul. 2017.
  3. M. F. Meyer, M. Kreppel, J. Meinrath, I. Grünewald, M. Stenner, U. Drebber, A. Quaas, M. Odenthal, R. Semrau, C. U. Huebbers, J. Zöller, K.-B. Huettenbrink, R. Buettner, and D. Beutner, “Prediction of outcome by lymph node ratio in patients with parotid gland cancer.,” Clin Otolaryngol, vol. 42, no. 1, pp. 98–103, Feb. 2017.
  4. L. Ozretić, S. Wagner, C. U. Huebbers, S. Gattenlöhner, J. P. Klussmann, D. Beutner, T. Zander, R. Buettner, and A. Quaas, “FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma.,” Oral Oncol., vol. 54, pp. e7–9, Mar. 2016.
  5. C. U. Huebbers, A. C. Adam, S. F. Preuss, T. Schiffer, S. Schilder, O. Guntinas-Lichius, M. Schmidt, J. P. Klussmann, and R. J. Wiesner, “High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.,” Oncotarget, vol. 6, no. 34, pp. 36172–36184, Nov. 2015.
  6. S. Wagner, N. Würdemann, C. Hübbers, M. Reuschenbach, E.-S. Prigge, G. Wichmann, J. Hess, A. Dietz, M. Dürst, I. Tinhofer, M. von Knebel-Döberitz, C. Wittekindt, and J. P. Klussmann, “[HPV-associated head and neck cancer : mutational signature and genomic aberrations].,” vol. 63, no. 11, pp. 758–767, Nov. 2015.
  7. S. F. Preuss, A. Anagiotos, I. M. C. Seuthe, U. Drebber, I. Wedemeyer, M. Kreppel, R. Semrau, G. D. Eslick, J. P. Klussmann, and C. U. Huebbers, “Expression of podoplanin and prognosis in oropharyngeal cancer.,” Eur Arch Otorhinolaryngol, vol. 272, no. 7, pp. 1749–1754, Jul. 2015.
  8. M. Reuschenbach*, C. U. Huebbers*, E.-S. Prigge*, J. L. Bermejo, M. S. Kalteis, S. F. Preuss, I. M. C. Seuthe, J. Kolligs, E.-J. M. Speel, N. Olthof, B. Kremer, S. Wagner, J. P. Klussmann, S. Vinokurova, and M. von Knebel Doeberitz, “Methylation status of HPV16 E2-binding sites classifies subtypes of HPV-associated oropharyngeal cancers.,” Cancer, vol. 121, no. 12, pp. 1966–1976, Jun. 2015.
  9. N. C. Olthof*, C. U. Huebbers*, J. Kolligs, M. Henfling, F. C. S. Ramaekers, I. Cornet, J. A. van Lent-Albrechts, A. P. A. Stegmann, S. Silling, U. Wieland, T. E. Carey, H. M. Walline, S. M. Gollin, T. K. Hoffmann, J. de Winter, B. Kremer, J. P. Klussmann, and E.-J. M. Speel, “Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines.,” Int. J. Cancer, vol. 136, no. 5, pp. E207–18, Mar. 2015.
  10. J. Straetmans, J. Vent, M. Lacko, E.-J. Speel, C. Huebbers, R. Semrau, F. Hoebers, Z. Mujagic, J. P. Klussmann, S. F. Preuss, and B. Kremer, “Management of neck metastases of unknown primary origin united in two European centers.,” vol. 272, no. 1, pp. 195–205, Jan. 2015.
  11. C. U. Hübbers and B. Akgül, “HPV and cancer of the oral cavity.,” Virulence, vol. 6, no. 3, pp. 244–248, 2015.
  12. J. J. Mooren, S. E. Gültekin, J. M. J. A. A. Straetmans, A. Haesevoets, C. J. Peutz-Kootstra, C. U. Huebbers, H. P. Dienes, U. Wieland, F. C. S. Ramaekers, B. Kremer, E.-J. M. Speel, and J. P. Klussmann, “P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias.,” Int. J. Cancer, vol. 134, no. 9, pp. 2108–2117, May 2014.
  13. M. F. Meyer, C. U. Huebbers, O. G. Siefer, J. Vent, I. Engbert, G. D. Eslick, M. Valter, J. P. Klussmann, and S. F. Preuss, “Prevalence and risk factors for oral human papillomavirus infection in 129 women screened for cervical HPV infection.,” Oral Oncol., vol. 50, no. 1, pp. 27–31, Jan. 2014.
  14. M. F. Meyer, I. M. C. Seuthe, U. Drebber, O. Siefer, M. Kreppel, M. O. Klein, S. Mikolajczak, J. P. Klussmann, S. F. Preuss, and C. U. Huebbers, “Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC).,” PLoS ONE, vol. 9, no. 12, p. e114170, 2014.
  15. N. C. Olthof, E.-J. M. Speel, J. Kolligs, A. Haesevoets, M. Henfling, F. C. S. Ramaekers, S. F. Preuss, U. Drebber, U. Wieland, S. Silling, W. L. Lam, E. A. Vucic, B. Kremer, J. P. Klussmann, and C. U. Huebbers, “Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.,” PLoS ONE, vol. 9, no. 2, p. e88718, 2014.
  16. J. Vent, B. Haidle, I. Wedemeyer, C. Huebbers, O. Siefer, R. Semrau, S. F. Preuss, and J. Klussmann, “p16 expression in carcinoma of unknown primary: diagnostic indicator and prognostic marker.,” Head Neck, vol. 35, no. 11, pp. 1521–1526, Nov. 2013.
  17. R. Semrau, H. Duerbaum, S. Temming, C. Huebbers, M. Stenner, U. Drebber, J. P. Klussmann, R.-P. Müller, and S. F. Preuss, “Prognostic impact of human papillomavirus status, survivin, and epidermal growth factor receptor expression on survival in patients treated with radiochemotherapy for very advanced nonresectable oropharyngeal cancer.,” Head Neck, vol. 35, no. 9, pp. 1339–1344, Sep. 2013.
  18. J. J. Mooren, B. Kremer, S. M. H. Claessen, A. C. Voogd, F. J. Bot, J. Peter Klussmann, C. U. Huebbers, A. H. N. Hopman, F. C. S. Ramaekers, and E.-J. M. Speel, “Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis.,” Int. J. Cancer, vol. 132, no. 8, pp. 1781–1789, Apr. 2013.
  19. C. U. Huebbers, S. F. Preuss, J. Kolligs, J. Vent, M. Stenner, U. Wieland, S. Silling, U. Drebber, E.-J. M. Speel, and J. P. Klussmann, “Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis.,” PLoS ONE, vol. 8, no. 2, p. e57207, 2013.
  20. M. Stenner, A. Demgensky, C. Molls, A. Hardt, J. C. Luers, M. Grosheva, C. U. Huebbers, and J. P. Klussmann, “Prognostic value of proliferating cell nuclear antigen in parotid gland cancer.,” vol. 269, no. 4, pp. 1225–1232, Apr. 2012.
  21. S. F. Preuss, J. P. Klussmann, R. Semrau, and C. Huebbers, “[Update on HPV-induced oropharyngeal cancer].,” vol. 59, no. 10, pp. 1031–7– quiz 1038, Oct. 2011.
  22. M. Stenner, B. Yosef, C. U. Huebbers, S. F. Preuss, H.-P. Dienes, E.-J. M. Speel, M. Odenthal, and J. P. Klussmann, “Nuclear translocation of β-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression?,” Histopathology, vol. 58, no. 7, pp. 1117–1126, Jun. 2011.
  23. M. Seitz, M. Grosheva, E. Skouras, S. K. Angelova, J. Ankerne, J. Jungnickel, C. Grothe, L. Klimaschewski, C. U. Hübbers, S. A. Dunlop, and D. N. Angelov, “Poor functional recovery and muscle polyinnervation after facial nerve injury in fibroblast growth factor-2-/- mice can be improved by manual stimulation of denervated vibrissal muscles.,” Neuroscience, vol. 182, pp. 241–247, May 2011.
  24. M. Stenner, A. Demgensky, C. Molls, A. Hardt, J. C. Luers, M. Grosheva, C. U. Huebbers, and J. P. Klussmann, “Prognostic value of survivin expression in parotid gland cancer in consideration of different histological subtypes.,” Eur. J. Cancer, vol. 47, no. 7, pp. 1013–1020, May 2011.
  25. J. Söhnchen, M. Grosheva, S. Kiryakova, C. U. Hübbers, N. Sinis, E. Skouras, J. Ankerne, K. Kaidoglou, J. W. U. Fries, A. Irintchev, S. A. Dunlop, and D. N. Angelov, “Recovery of whisking function after manual stimulation of denervated vibrissal muscles requires brain-derived neurotrophic factor and its receptor tyrosine kinase B.,” Neuroscience, vol. 170, no. 1, pp. 372–380, Sep. 2010.
  26. S. Kiryakova, J. Söhnchen, M. Grosheva, U. Schuetz, T. Marinova, R. Dzhupanova, N. Sinis, C. U. Hübbers, E. Skouras, J. Ankerne, J. W. U. Fries, A. Irintchev, S. A. Dunlop, and D. N. Angelov, “Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1).,” Exp. Neurol., vol. 222, no. 2, pp. 226–234, Apr. 2010.
  27. J. P. Klussmann, J. J. Mooren, M. Lehnen, S. M. H. Claessen, M. Stenner, C. U. Huebbers, S. J. Weissenborn, I. Wedemeyer, S. F. Preuss, J. M. J. A. A. Straetmans, J. J. Manni, A. H. N. Hopman, and E.-J. M. Speel, “Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications.,” Clin. Cancer Res., vol. 15, no. 5, pp. 1779–1786, Mar. 2009.
  28. C. U. Hübbers, C. S. Clemen, K. Kesper, A. Böddrich, A. Hofmann, O. Kämäräinen, K. Tolksdorf, M. Stumpf, J. Reichelt, U. Roth, S. Krause, G. Watts, V. Kimonis, M. P. Wattjes, J. Reimann, D. R. Thal, K. Biermann, B. O. Evert, H. Lochmüller, E. E. Wanker, B. G. H. Schoser, A. A. Noegel, and R. Schröder, “Pathological consequences of VCP mutations on human striated muscle.,” Brain, vol. 130, no. 2, pp. 381–393, Feb. 2007.